Health Ranger/Mike Adams/Ivermectin... This is what I would do. If you do the math, the tube contains 6.08 grams of paste or 6,080 milligrams. The percentage of ivermectin in the gel is 1.87%. To derive the milligrams of ivermectin in a full tube you take 6080 x .0187 = 113.696 milligrams of ivermectin per tube. That is enough for a 1250 lb horse. The plunger stem has 28 serrations so when you open a new tube and push the plunger stem up to the first notch each notch thereafter will dispense 113.696 milligrams / 28 or 4.06 milligrams of ivermectin ( Just call each notch equal to an even 4 milligrams worth of ivermectin ). A normal dose ratio for ivermectin is .2 milligrams per kilogram of body weight. Please Do your own research